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James Lee

James Lee

Single-cell Omics
Functional Genomics
Cancer Immunology

About Me

Innovative researcher advancing precision medicine through computational biology

Research Focus

I'm an innovative researcher with expertise in Next-Generation Sequencing and cancer immunology, with a strong track record of developing novel methodologies and leading high-impact projects. Currently pursuing my Master's in Bioinformatics and Systems Biology at New York University while conducting cutting-edge research at the New York Genome Center.

My research focuses on understanding tumor microenvironments, developing novel therapeutic approaches, and advancing precision medicine through computational biology and single-cell analysis. I'm adept at developing analytical pipelines and collaborating with cross-functional teams.

5+
Years Research
5+
Publications
3
Institutions
Curiosity

Publications

Contributing to the advancement of scientific knowledge

First and Co-first Author Publications

Inhibition of SUMOylation Induces Adaptive Anti-Tumor Immunity Against Pancreatic Cancer through Multiple Effects on the Tumor Microenvironment
Erdem, S., Lee, H. J., Suryanarayanan, J., et al.
Molecular Cancer Therapeutics 2024
Download PDF
Liposomal Doxorubicin, but Not Platinum-Taxane, Supports MHC-II Expression and Immune Maturation in the Ovarian Tumor Microenvironment
Lee, H., Chen, X., Ozmadenci, D., et al.
Cancers 2025
Open Access

Co-author Publications

SUMO Inhibition Plus CD40 Agonism Increases Anti-Tumor Immunogenicity Through Interferon Mediated Macrophage Activation
Li, K., Courelli, A., Lee, H. J., et al.
bioRxiv 2024
An Ex Vivo Organotypic Culture Platform for Functional Interrogation of Human Appendiceal Cancer Reveals a Prominent and Heterogenous Immunological Landscape
Weitz, J.*, Hurtado de Mendoza, T.*, Tiriac, H., Lee, J., et al.
Clinical Cancer Research 2022

Featured Projects

Showcasing innovative research and development

🧬 scPerturb-CMap

A lightweight Python package for single-cell perturbational profiling and drug discovery workflows. Features modern Python project structure, device auto-selection (CUDA/MPS/CPU), and ML utilities for CMap analysis.

View Project

📱 Smart Cell Counter

AI-powered hemocytometer analysis mobile app built with React Native and TensorFlow. Automated cell counting, viability assessment, and professional PDF reporting for laboratory research.

View Project

🧬 scImmuneATLAS

A comprehensive, production-ready single-cell immune atlas for tumor-infiltrating lymphocytes (TILs). Multi-dataset integration with advanced QC, batch correction, and immune cell annotation.

View Project

🧬 Single-cell HGSOC Study

Single-cell RNA-seq analysis of High-Grade Serous Ovarian Cancer focusing on platinum-based chemotherapy resistance mechanisms.

View Project

Experience

Journey through cutting-edge research and innovation

August 2024 - Present

Graduate Student Researcher/Research Assistant

New York Genome Center - Sanjana Lab

Investigate synthetic genes in various cell types and diseases

January 2023 - July 2024

Research Associate

Scale Biosciences

Played a key role in developing Quantum Barcoding technology single-cell RNA assay using combinatorial indexing.

January 2023 - October 2023

Research Associate

UC San Diego, Moores Cancer Center, Stupack Lab

Delivered scRNA-seq analysis of high-grade serous ovarian cancer, delivering key insights into platinum-based chemotherapy resistance (1st author publication).

August 2021 - November 2022

Research Associate

UC San Diego, Moores Cancer Center, Chen Lab

Led a project investigating tumor microenvironment changes in pancreatic ductal adenocarcinoma, uncovering significant changes in tumor-infiltrating lymphocytes and macrophage polarization upon SUMOylation inhibition (1st author publication).

Technical Skills

Tools and technologies driving innovation

Programming & Data Science

Python R Bash SQL Machine Learning PyTorch TensorFlow

Bioinformatics & Genomics

Single-cell RNA-seq NGS Analysis CRISPR Screens Multi-omics BioConductor BLAST

Infrastructure & Tools

AWS HPC Linux/Unix Git Docker

Laboratory Techniques

NGS Library Prep Flow Cytometry Cell Culture Western Blot Microscopy

Education

New York University

Master of Science in Bioinformatics and Systems Biology

September 2024 - May 2025 | New York, NY

Bioinformatics Systems Biology Computational Biology

UC San Diego

Bachelor of Science - Double Major

General Biology | Political Science - Data Analytics

January 2019 - July 2021 | La Jolla, CA

Molecular Biology Data Analytics Statistics

Let's Connect

Interested in collaboration, research opportunities, or just want to chat about bioinformatics and cancer research? I'm always open to discussing innovative projects and potential partnerships.

📍 New York, NY 10013

"Advancing precision medicine through computational biology and single-cell genomics"